360 Human Milk T Lymphocytes
نویسندگان
چکیده
It has been recognized for more than half a century that, in addition to occasional mammary gland alveolar or ductal epithelial cell fragments, colostrum and milk consistently contain significant concentrations of viable leukocytes. These include lipid-laden macrophages that can exhibit ameboid and phagocytic activity, polymorphonuclear neutrophils, and lymphocytes of various sizes (1, 2). The overall concentration of these leukocytes is of the same order of magnitude as that seen in peripheral blood, although the predominant cell in milk is the macrophage rather than the neutrophil. While there has been much speculation concerning the functional significance of milk cells, only recently has suggestive evidence been forthcoming that they may constitute an important post-partum component of the maternal immunologic endowment, fulfilling a protective role within the lumen of the suckling's alimentary canal (3). The observations in rats that nursing can mediate adoptive immunization and, in certain genetic contexts, lead to graft-versus-host disease suggest that the lymphocyte moiety may actually gain access to the neonate's tissues (4). Various investigators have established the presence of significant proportions of both T and B lymphocytes in human colostrum and milk (5) and have demonstrated their capacity to respond to mitogens in vitro (2, 5), synthesize IgA antibody (6), and display in vitro parameters of the delayed hypersensitivities of the donor (1, 2). The principal objective of the present study was to establish the capacity of milk lymphocytes to function both as stimulator and responder cells in mixed lymphocyte cultures and to compare them with peripheral blood lymphocytes (PBL) 1 in this regard.
منابع مشابه
In vitro studies on the T-lymphocyte population of human milk
Human milk lymphocytes (ML) can be partially purified and propagated in vitro as a means of assessing their immunological function. When exposed to a variety of stimuli known to activate T lymphocytes, ML respond in a unique manner that indicates a selected population of immunocompetent cells. ML are hyporesponsive to to nonspecific mitogens and respond in a reduced manner to histocompatibility...
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